Monte Carlo‐Based Assessment of Human Health and Ecological Risks from Chromium and Iron Contamination in Coastal South Sulawesi, Indonesia
Keywords:
Chromium, Health risk assessment, Heavy metals, Iron, Monte carlo simulationAbstract
This study aimed to assess exposure levels and health risks associated with iron (Fe) and chromium (Cr) among coastal communities in South Sulawesi, Indonesia. A cross-sectional design was employed, involving field sampling and laboratory analysis of seawater and marine biota, combined with a health risk assessment approach. Intake analysis indicated that Fe was the dominant contributor to daily exposure, while Cr levels were relatively lower. Risk characterization showed that the average Risk Ratio (RQ) for Fe exceeded the safe threshold (RQ > 1), while the RQ for Cr remained below the safe limit. Monte Carlo simulations (MCS) confirmed that both Cr and Fe exhibited Target Hazard Quotient (THQ) values above safe levels. Sensitivity analysis revealed that exposure duration, frequency, consumption level, and metal concentration in seafood were the most influential variables. This study demonstrated that Fe is the primary risk factor contributing to non-carcinogenic health hazards in coastal areas of South Sulawesi, while Cr presents a potential long-term carcinogenic risk. These findings underscore the urgent need for integrated mitigation strategies to protect public health and ensure the sustainability of coastal ecosystems.Downloads
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Gao, Z. Y., Li, M. M., Wang, J., Yan, J., Zhou, C. C., and Yan, C. H. (2018). Blood mercury concentration, fish consumption and anthropometry in Chinese children: A national study. Environment International, 110, 14–21.
Sufriadin, S., Widodo, S., Thamrin, M., Ito, A., and Otake, T. (2021). The Latowu ultramafic rock-hosted iron mineralization in the Southeastern Arm, Sulawesi, Indonesia: Characteristics, origin, and implications for beneficiation. International Journal on Advanced Science, Engineering and Information Technology, 11(3), 987–993.
Fatimah, D. Y., Setiawan, E., Prasojo, A. S. A., Ulvah, F., and Kurniawan, R. (2025). Geochemical properties and critical mineral potential of Ni-laterite deposits in advancing clean energy technology development. Journal of Geoscience, Engineering, Environment, and Technology, 10(1), 51-59
Vigneri, R., Malandrino, P., Gianì, F., Russo, M., and Vigneri, P. (2017). Heavy metals in the volcanic environment and thyroid cancer. Molecular and Cellular Endocrinology, 457, 73–80.
Lanzoni, A., Castoldi, A. F., Kass, G. E. N., Terron, A., and de Seze, G. (2019). Advancing human health risk assessment. EFSA Journal, 17, e170712.
Mallongi, A., Stang, S., Syamsuar, N., Natsir, M. F., Astuti, R. D. P., Rauf, A. U., Rachmat, M., and Muhith, A. (2020). Potential ecological risks of mercury contamination along communities area in Tonasa Cement Industry, Pangkep, Indonesia. Enfermería Clínica, 30, 139–146.
Rauf, A. U., Mallongi, A., Daud, A., Hatta, M., Al-Madhoun, W., Amiruddin, R., Stang, S., Rahman, A., Wahyu, A., and Astuti, R. D. P. (2021). Community health risk assessment of total suspended particulates near a cement plant in Maros Regency, Indonesia. Journal of Health and Pollution, 11(30), 210616.
Rauf, A. U., Mallongi, A., Lee, K., Daud, A., Hatta, M., Al-Madhoun, W., and Astuti, R. D. P. (2021). Potentially toxic element levels in atmospheric particulates and health risk estimation around industrial areas of Maros, Indonesia. Toxics, 9(12), 328.
Gu, X., Wang, Z., Wang, J., Ouyang, W., Wang, B., Xin, M., Lian, M., Lu, S., Lin, C., He, M., and Liu, X. (2022). Sources, trophodynamics, contamination and risk assessment of toxic metals in a coastal ecosystem by using a receptor model and Monte Carlo simulation. Journal of Hazardous Materials, 424, 127482.
U.S. Environmental Protection Agency (EPA). (1997). Ecological risk assessment guidance for Superfund: Process for designing and conducting ecological risk assessments. United States Environmental Protection Agency.
Orosun, M. M., Adewuyi, A. D., Salawu, N. B., Isinkaye, M. O., Orosun, O. R., and Oniku, A. S. (2020). Monte Carlo approach to risk assessment of heavy metals at automobile spare parts and recycling market in Ilorin, Nigeria. Scientific Reports, 10(1), 22084.
Shalyari, N., Alinejad, A., Hashemi, A. H. G., RadFard, M., and Dehghani, M. (2019). Health risk assessment of nitrate in groundwater resources of Iranshahr using Monte Carlo simulation and geographic information system (GIS). MethodsX, 6, 1812–1821.
Briffa, J., Sinagra, E., and Blundell, R. (2020). Heavy metal pollution in the environment and their toxicological effects on humans. Heliyon, 6(9), e04691.
Liu, Q., Xu, X., Zeng, J., Shi, X., Liao, Y., Du, P., Tang, Y., Huang, W., Chen, Q., and Shou, L. (2019). Heavy metal concentrations in commercial marine organisms from Xiangshan Bay, China, and the potential health risks. Marine Pollution Bulletin, 141, 215–226.
Hosono, T., Su, C. C., Delinom, R., Umezawa, Y., Toyota, T., Kaneko, S., and Taniguchi, M. (2011). Decline in heavy metal contamination in marine sediments in Jakarta Bay, Indonesia due to increasing environmental regulations. Estuarine, Coastal and Shelf Science, 92(2), 297–306.
Feng, Y., Bao, Q., Chen, Y., Zhang, L., and Xiao, X. (2019). Stochastic potential ecological risk model for heavy metal contamination in sediment. Ecological Indicators, 102, 246–251.
Watts, M. J., Menya, D., Humphrey, O. S., Middleton, D. R. S., Hamilton, E. M., Marriott, A. L., and Osano, O. (2021). Human urinary biomonitoring in Western Kenya for micronutrients and potentially harmful elements. International Journal of Hygiene and Environmental Health, 238, 113854.
Pandion, K., Khalith, S. M., Ravindran, B., Chandrasekaran, M., Rajagopal, R., Alfarhan, A., and Arunachalam, K. D. (2022). Potential health risk caused by heavy metal associated with seafood consumption around coastal areas. Environmental Pollution, 294, 118553.
Waqas, W., Yuan, Y., Ali, S., Zhang, M., Shafiq, M., Ali, W., Chen, Y., Xiang, Z., Chen, R., Ikhwanuddin, M., and Ma, H. (2024). Toxic effects of heavy metals on crustaceans and associated health risks in humans: A review. Environmental Chemistry Letters, 22, 1391–1411.
Sengar, A., and Vijayanandan, A. (2022). Human health and ecological risk assessment of 98 pharmaceuticals and personal care products (PPCPs) detected in Indian surface and wastewaters. Science of the Total Environment, 807, 150677.
Setia, R., Dhaliwal, S. S., Singh, R., Singh, B., Kukal, S. S., and Pateriya, B. (2023). Ecological and human health risk assessment of metals in soils and wheat along Sutlej River (India). Chemosphere, 312, 137331.
Taghavi, M., Mostahsari, P., Sadat, S. A., Kheirabadi, M., Mahdiar, A., and Sepehrikia, S. (2023). Ecological risk assessment of Cd, As, Cr, and Pb metals in farmed wheat in the vicinity of an industrial park. International Journal of Environmental Analytical Chemistry, 103(14), 3196–3211.
Oruko, R. O., Edokpayi, J. N., Msagati, T. A., Tavengwa, N. T., Ogola, H. J., and Ijoma, G. (2021). Investigating the chromium status, heavy metal contamination, and ecological risk assessment via tannery waste disposal in sub-Saharan Africa (Kenya and South Africa). Environmental Science and Pollution Research, 28(31), 42135–42149.
Chandio, T. A., Khan, M. N., Muhammad, T. M., Yalcinkaya, O., Turan, E., and Kayis, A. F. (2021). Health risk assessment of chromium contamination in the nearby population of mining plants, situated at Balochistan, Pakistan. Environmental Science and Pollution Research, 28(13), 16458–16469.
Rahman, M. A., Kumar, S., Lamb, D., and Rahman, M. M. (2021). Health risk assessment of arsenic, manganese, and iron from drinking water for high school children. Water, Air, and Soil Pollution, 232(7), 269.
Zhang, X., Liu, P., Yang, Y., Chen, W., and Li, Y. (2024). Health risk assessment of heavy metals through seafood consumption in coastal regions of South China. Scientific Reports, 14, 70409.
Hassan, M. A., Abdel-Khalek, A. A., El-Saidy, D. M., and El-Sayed, M. F. (2025). Health hazard assessment and cooking effects on toxic metals in marine fish from the Mediterranean Sea at the Damietta Coast, Egypt. Scientific Reports, 15, 33257.
Khan, S., Rehman, S., Shah, M. T., Khan, M. A., and Muhammad, S. (2022). Human health risk assessment of heavy metals in marine fish species from coastal areas of the Arabian Sea. Environmental Science and Pollution Research, 29, 42036–42048.
El-Shenawy, N. S., Soliman, N. F., and Al-Enezi, G. (2024). Human health risk assessment of heavy metals through consumption of fish and shellfish from coastal environments. Scientific Reports, 14, 69561.
Chen, F., Muhammad, F. G., Khan, Z. I., Ahmad, K., Nadeem, M., Mahmood, S., et al. (2022). Ecological risk assessment of heavy metal chromium in a contaminated pastureland area in the Central Punjab, Pakistan: Soils vs plants vs ruminants. Environmental Science and Pollution Research, 29(3), 4170–4179.
Hamid, E., Payandeh, K., Karimi Nezhad, M. T., and Saadati, N. (2022). Potential ecological risk assessment of heavy metals (trace elements) in coastal soils of southwest Iran. Frontiers in Public Health, 10, 889130.
Ogarekpe, N. M., Nnaji, C. C., Oyebode, O. J., Ekpenyong, M. G., Ofem, O. I., and Tenebe, I. T. (2023). Groundwater quality index and potential human health risk assessment of heavy metals in water: A case study of Calabar metropolis, Nigeria. Environmental Nanotechnology, Monitoring and Management, 19, 100780.
Rouhani, A., Bradák, B., Makki, M., Ashtiani, B., and Hejcman, M. (2022). Ecological risk assessment and human health risk exposure of heavy metal pollution in the soil around an open landfill site in a developing country (Khesht, Iran). Arabian Journal of Geosciences, 15(18), 1523.
Gopal, V., Krishnamurthy, R. R., Indhumathi, A., Sharon, B. T., Priya, T. D., and Rathinavel, K. (2024). Geochemical evaluation, ecological and human health risk assessment of potentially toxic elements in urban soil, Southern India. Environmental Research, 248, 118413.
Gupta, S., and Gupta, S. K. (2023). Application of Monte Carlo simulation for carcinogenic and non-carcinogenic risks assessment through multi-exposure pathways of heavy metals of river water and sediment, India. Environmental Geochemistry and Health, 45(6), 3465–3486.
Panqing, Y., Abliz, A., Xiaoli, S., and Aisaiduli, H. (2023). Human health-risk assessment of heavy metal–contaminated soil based on Monte Carlo simulation. Scientific Reports, 13(1), 7033.
Sanaei, F., Amin, M. M., Alavijeh, Z. P., Esfahani, R. A., Sadeghi, M., and Bandarrig, N. S. (2021). Health risk assessment of potentially toxic elements intake via food crops consumption: Monte Carlo simulation-based probabilistic and heavy metal pollution index. Environmental Science and Pollution Research, 28(2), 1479–1490.
Saeed, O., Székács, A., Jordán, G., Mörtl, M., Abukhadra, M. R., and Eid, M. H. (2023). Investigating the impacts of heavy metal(loid)s on ecology and human health in the lower basin of Hungary’s Danube River: A Python and Monte Carlo simulation-based study. Environmental Geochemistry and Health, 45(12), 9757–9784.
Eid, M. H., Eissa, M., Mohamed, E. A., Ramadan, H. S., Tamás, M., and Kovács, A. (2024). New approach into human health risk assessment associated with heavy metals in surface water and groundwater using Monte Carlo method. Scientific Reports, 14(1), 1008.
Ma, Z., Li, J., Zhang, M., You, D., Zhou, Y., and Gong, Z. (2022). Groundwater health risk assessment based on Monte Carlo model sensitivity analysis of Cr and As: A case study of Yinchuan City. Water, 14(15), 2419.
Sayed, F. A., Eid, M. H., El-Sherbeeny, A. M., Abdel-Gawad, G. I., Mohamed, E. A., and Abukhadra, M. R. (2025). Environmental and health risk assessment of polycyclic aromatic hydrocarbons and toxic elements in the Red Sea using Monte Carlo simulation. Scientific Reports, 15(1), 4122.
Ebrahimzadeh, G., Omer, A. K., Naderi, M., and Sharafi, K. (2024). Human health risk assessment of potentially toxic and essential elements in medicinal plants consumed in Zabol, Iran, using the Monte Carlo simulation method. Scientific Reports, 14(1), 23756.
Asadi Touranlou, F., Tavakoly Sany, S. B., Ghayour Mobarhan, M., Khanzadi, S., Afshari, A., and Hashemi, M. (2025). Health risk assessment of exposure to heavy metals in wheat flour from Iran markets: Application of Monte Carlo simulation approach. Biological Trace Element Research, 203(4), 2284–2294.
Nemati, B., Fallahizadeh, S., Mostafaei, G., and Miranzadeh, M. B. (2025). Health risk assessment of toxic elements in Kashan drinking water reservoirs using Monte Carlo simulation and sensitivity analysis. Scientific Reports, 15(1), 17806.
Yang, Q., Zhang, L., Wang, H., and Martín, J. D. (2022). Bioavailability and health risk of toxic heavy metals (As, Hg, Pb and Cd) in urban soils: A Monte Carlo simulation approach. Environmental Research, 214, 113772.
Ge, Q., Chen, G., Guo, W., Zhao, J., Yao, Y., and Yang, L. (2025). Health risk assessment of heavy metal(loid)s in a soil–rice system in the selenium-enriched area based on Monte Carlo simulation and bioaccessibility. Environmental Geochemistry and Health, 47(10), 1–23.
Paydar, M., and Vagheei, R. (2025). Assessment of human health risk from chromium in drinking water in the northeast of Iran using the Monte Carlo simulation. Journal of Health Scope, 14(1), e158609.
Pan, X. D., Han, J. L., and Shen, H. T. (2024). Distribution and risk assessment of multiple elements in rice from southeast China using Monte Carlo simulation. Journal of Food Composition and Analysis, 129, 106103.
Wu, Y., Xia, Y., Mu, L., Liu, W., Wang, Q., and Su, T. (2024). Health risk assessment of heavy metals in agricultural soils based on multi-receptor modeling combined with Monte Carlo simulation. Toxics, 12(9), 643.
Zhu, H., Liu, X., Xu, C., Zhang, L., Chen, H., and Shi, F. (2021). The health risk assessment of heavy metals in road dust based on Monte Carlo simulation and bio-toxicity: A case study in Zhengzhou, China. Environmental Geochemistry and Health, 43(12), 5135–5156.
Askari, M., Soleimani, H., Nalosi, K. B., Saeedi, R., Abolli, S., and Ghani, M. (2024). Bottled water safety evaluation: A comprehensive health risk assessment of oral exposure to heavy metals through deterministic and probabilistic approaches by Monte Carlo simulation. Food and Chemical Toxicology, 185, 114492.
Chorol, L., and Gupta, S. K. (2023). Evaluation of groundwater heavy metal pollution index through analytical hierarchy process and its health risk assessment via Monte Carlo simulation. Process Safety and Environmental Protection, 170, 855–864.
Pirsaheb, M., Hadei, M., and Sharafi, K. (2021). Human health risk assessment by Monte Carlo simulation method for heavy metals of commonly consumed cereals in Iran—Uncertainty and sensitivity analysis. Journal of Food Composition and Analysis, 96, 103697.
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